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These patients have mild cognitive impairment due to Alzheimer's disease or mild Alzheimer's disease. Amyloid pathology will be confirmed by positron emission tomography (PET) or cerebrospinal fluid (CSF) assessment. Patients are allocated equally in the groups that receive either placebo or active substance. The group that receives active substance will be dosed every other week with 10 mg/kg of BAN2401. The primary endpoint is the change from baseline in the cognition and function scale Clinical Dementia Rating-Sum of Boxes (CDR-SB) after 18 months of treatment. Changes in the clinical scales AD composite score (ADCOMS) and AD Assessment Scale-Cognitive Subscale (ADAS-cog) are key secondary endpoints together with brain amyloid levels measured by amyloid PET. About BioArctic AB
BioArctic AB (publ) is a Swedish research-based biopharma company focusing on disease-modifying treatments and reliable biomarkers and diagnostics for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.
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